ETH News

A team of three European researchers will develop an imaging method to non-invasively measure the stiffness of moving organs such as the heart. The researchers will be supported by the European Research Council.

Pioneer Fellow Hao Liu uses lasers to produce microfilament structures to grow biological tissue in the lab for research and medicine ¨C from muscle tissue to cartilage. Now he¡¯s working to ready this technology for the market.

Nina Cabezas Wallscheid, Professor of Stem Cell Biology and Ageing, is researching the impact of nutrition on the human blood system. Her research team aims to identify the ideal diet for a long and healthy life.

Not all pain is the same. Depending on the cause, it requires different therapies. A team led by ETH Zurich has now developed a method that enables physicians to better distinguish between physical and psychosocial pain.

A new class of fat cells makes people healthier. The cells consume energy and produce heat through seemingly pointless biochemical reactions.

The brain chemical orexin is crucial when we choose between sport and the tasty temptations that beckon everywhere we turn. This research finding could also help people who find it difficult to motivate themselves to exercise.

Researchers at ETH Zurich have uncovered how colorectal cancer cells colonise the liver. Their findings could open up new ways to suppress this process in the future.

Researchers at ETH Zurich have developed a cell-based bone model to help investigate the cause of this genetic condition.

The Gloria Cube is ETH Zurich¡¯s newest building in the Zurich City university district. Teaching, research and translation are all carried out in the service of health and medicine here. At the end of last week, ETH Zurich celebrated the laboratory and research building¡¯s inauguration.

In collaboration with University Hospital Basel, researchers from ETH are investigating the early stages of bladder cancer. Their findings show that future research should also focus on mechanical changes in tumour tissue.

Monitoring and treating a case of multiple sclerosis requires reliable and long-term data on how the disease is progressing in the person in question. Fitness trackers and smartphones can supply this data, as a research team led by ETH Zurich has now shown.

Researchers from ETH Zurich and KUNO Klinik St. Hedwig in Regensburg have developed an algorithm that provides an automatic and reliable method of detecting a certain heart defect in newborns.

During the COVID-19 pandemic, hospitals often became hubs of infection. Researchers from ETH Zurich, EPFL and the ISI Foundation are developing a wearable tracking system for healthcare facilities that can identify the risks of infections. Initial tests in Switzerland and Africa show its potential.

Prostheses that connect to the nervous system have been available for several years. Now, researchers at ETH Zurich have found evidence that neuroprosthetics work better when they use signals that are inspired by nature.

Roughly one in two wearers of ventricular assist devices are diagnosed with an infection. The reason for this is the thick cable for the power supply. ETH Zurich researchers have now developed a solution to mitigate this problem.

Researchers at ETH Zurich recently developed highly realistic simulations of the proteins on sperm and egg cells coupling together before they fuse. These findings enabled the research team to solve several mysteries of fertilisation at once, which could help to accelerate development of more targeted infertility treatments.

If the body¡¯s natural stress response gets knocked off balance, it can result in physical and mental health disorders. Researchers at ETH Zurich have developed an agent capable of selectively inhibiting this response.

ETH Zurich researchers have found a virus that kills dormant bacteria. This rare discovery could help to combat germs that can¡¯t be treated with antibiotics alone.

Researchers at ETH Zurich have now shown that a previously unknown protein plays a key role in a congenital malformation of the heart. Their findings point the way towards new treatment options.

How to bring a diagnostic process that has endured for 100 years into the digital age? Two researchers from ETH Zurich and the University of Zurich are developing a robotic platform that enables a more accurate diagnosis of cancer cells by rapidly quantifying tissue samples in their entirety.

Stimulating the brain with gentle sounds during deep sleep significantly enhances cardiac function, according to a new study. This discovery could have implications not only for cardiovascular diseases but also for competitive sports, among other areas.

Researchers at ETH Zurich have developed a method that lets them genetically modify each cell differently in animals. This allows them to study in a single experiment what used to require many animal experiments. Using the new method, the researchers have discovered genes that are relevant for a severe rare genetic disorder.

The CRISPR-Cas gene scissors enable researchers to study the genetic and cellular causes of autism in the lab ¨C directly on human tissue.

ETH Zurich professors Mustafa Khammash and Marc Pollefeys are each recipients of a prestigious Advanced Grant currently awarded by the Swiss National Science Foundation, rather than the European Research Council.

Science often runs ahead of legislation ¨C and this is now also true for research on embryo-like cell aggregates from human stem cells. Bioethicist Alessandro Blasimme of ETH Zurich explains why this controversial topic calls for legal clarity.

The pathogens that cause urinary tract infections are becoming increasingly resistant to antibiotics. ETH Zurich researchers have now developed a rapid test and a new therapeutic approach using bacteria-infecting viruses known as phages.

A research team from ETH Zurich and the Paul Scherrer Institute PSI together with the Baden Cantonal Hospital and the University Hospital Zurich wants to improve a method for diagnosing breast cancer. ?

The way the brain regulates pupil size is different from previously thought: fundamentally responsible is the neurotransmitter orexin, as researchers at ETH Zurich have now shown. This discovery could well alter our understanding of consciousness and illnesses such as narcolepsy and Alzheimer¡¯s.

Kantonsspital Baden (KSB) and ETH Zurich have been working together since 2017, mainly in teaching initially, but increasingly in clinical research. Now three ETH professors are moving into new premises on the hospital¡¯s healthcare campus. Together, they want to make findings from basic research available for the benefit of patients.

Researchers at ETH Zurich and Empa have developed a patch with a sensor function. It can be used to seal wounds in the abdomen after surgery. The polymer patch warns before the occurrence of dangerous leaks on sutures in the gastrointestinal tract.

Researchers from Basel and Zurich are creating a high-resolution atlas that depicts the development of the human retina. One technique they use is a new method that allows them to visualise more than 50 proteins simultaneously.

The cells of our body interact with their immediate environment. Researchers have now studied this interaction in detail. In time, they hope to use these findings for improved diagnosis and treatment of wound-healing disorders and cancer.

Researchers at ETH Zurich have analysed the bird flu epidemic caused by the H7N9 strain that affected China from 2013 to 2017. New phylogenetic trees will help to improve monitoring of future bird flu epidemics.

For minimally invasive surgery, the instruments used must be small. ETH Zurich researchers have now developed a method to transport large devices through a narrow catheter. This expands the possibilities for designing minimally invasive surgical tools.

Researchers at ETH Zurich have developed an electronic yarn capable of precisely measuring how a person¡¯s body moves. Integrated directly into sportswear or work clothing, the textile sensor predicts the wearer¡¯s exhaustion level during physical exertion.

Increasingly dense cell clusters in growing tumours convert blood vessels into fibre-filled channels. This makes immune cells less effective, as findings by researchers from ETH Zurich and the University of Strasbourg suggest.

Cancer patients might one day benefit from being administered immune cells from healthy donors. But as things stand, receiving donor cells can cause severe or even fatal immune reactions. A researcher at ETH Zurich has now developed a technology that avoids these.

ETH student Luca Hasler developed a new set of handlebars for para-athlete Flurina Rigling.?The cyclist hopes these will boost her chances of qualifying for future events ¨C including the 2024 Paralympics in Paris.

Emotional trauma can have far-reaching ripple effects and may even reverberate across generations. Professors Isabelle Mansuy and Katharina Gapp study how the effects of trauma can be inherited through epigenetic mechanisms.

It is known that toxins in tobacco smoke can change our DNA ¨C but where exactly in the genome they do this has been a mystery. A new approach developed by researchers at ETH Zurich now brings light into the darkness. In the future, this could make it easier than ever to determine the safety of many chemical substances.

Up to now, the use of models to research the barrier that separates the circulatory from the nervous system has proven to be either limited or extremely complicated. Researchers at ETH Zurich have developed a more realistic model that can also be used to better explore new treatments for brain tumours.

The LOOP Zurich research centre is creating a central platform for the exchange of health data between the University of Zurich, ETH Zurich and the four university hospitals. This will allow data to be utilised quickly and easily to the benefit of patients.?

New research offers potential benefits for those affected by the hereditary metabolic disease methylmalonic aciduria. By combining the results of multiple molecular analyses, scientists can better diagnose this rare and severe disease. In the future, an improved understanding of the disease might also improve treatment options.

The LOOP Zurich research center combines expertise from ETH Zurich, the University of Zurich and the four university hospitals in Zurich with the aim of developing more personalized therapies. Two new projects supported by The LOOP Zurich target urinary tract infections and obesity respectively.

The ETH Board has appointed Christian Wolfrum as Vice President for Research at ETH Zurich effective 1 January 2023. In his roles as Professor of Translational Nutritional Biology, Director of Studies and Associate Vice President for Medicine, Wolfrum has actively shaped medical teaching and research at the university.

Gregor Weiss used state-of-the-art microscopy to show how the body prevents bladder infections. He now wants to make this method from basic research usable for the analysis of patient samples ¨C and has received the Lopez-Loreta Prize for it.

Researchers at ETH Zurich are planning to use magnetic bacteria to fight cancerous tumours. They have now found a way for these microorganisms to effectively cross blood vessel walls and subsequently colonise a tumour.

It is not only classical genes that determine our predisposition to obesity. Researchers at ETH Zurich have now shown that microRNA molecules play a central role in the regulation of body weight.

Scientists have a duty to initiate a dialogue with the public on cellular engineering, says Daniel M¨¹ller. The discussion must be held now ¨C before complex engineered cellular systems are ready for widespread use in humans.

Chemists at ETH Zurich have found a facile method that allows a commonly used building block to be directly converted into other types of important compounds. This expands the possibilities of chemical synthesis and facilitates the search for new pharmaceutically active ingredients.

The latest CRISPR-based genome editing systems function more like molecular taxis rather than a pair of molecular scissors. This makes them much safer for patients who will soon benefit from gene therapies, as Eric Aird explains.

Researchers at ETH have shown that cases of opioid poisoning and the prescription of opioids have increased sharply in Switzerland over the past 20 years. Although the situation is not as serious as in North America, the risk should not be underestimated.

Researchers at ETH Zurich have developed a wearable textile exomuscle that serves as an extra layer of muscles. They aim to use it to increase the upper body strength and endurance of people with restricted mobility.

The multidisciplinary Zurich research team Liver4Life has succeeded in doing something during a treatment attempt that had never been achieved in the history of medicine until now: it treated an originally damaged human liver in a machine for three days outside of a body and then implanted the recovered organ into a cancer patient. One year later, the patient is doing well.

The VIEshunt student team aims to benefit patients by developing an intelligent shunt able to regulate the intracranial pressure.

Entrepreneur and philanthropist Hansj?rg Wyss is one of the major private donors for Swiss science. Today, Wyss was celebrated as the laureate of the 2022 Gallatin Award of the Swiss American Chamber of Commerce.

Researchers from ETH Zurich, University Hospital of Bern and the University of Bern have equipped gut bacteria with data logger functionality as a way of monitoring which genes are active in the bacteria. These microorganisms could one day offer a noninvasive means of diagnosing disease or assessing the impact of a diet on health.

Researchers have developed a new method that uses artificial intelligence to analyse animal behaviour. This opens the door to longer-term in-depth studies in the field of behavioural science ¨C while also helping to improve animal welfare. The method is already being tested at Zurich Zoo.

A presumed consent system for organ donation, which is to be put to the vote in Switzerland, would likely increase the organ donation rate, writes bioethicist Agata Ferretti. In her view, however, there is an even better solution: the obligation to decide.

Researchers have developed a wearable device that plays specific sounds to enhance deep sleep. The first clinical study has now shown that the device is effective, but not at the same level of effectiveness for everyone.

In experiments on mice, researchers at ETH Zurich show that non-essential amino acids act as appetite suppressants and promote the urge to move. Their research provides insight into the neural mechanism that controls this behaviour.

Erika Meins explains the science behind why returning to the office is good for our performance as well as our well-being.? ?

Johannes Bohacek explains why it¡¯s misleading to think we can completely replace animal testing with alternative methods, and why we should lower rather than raise the hurdles to research.

ETH Zurich and the other Swiss universities are committed to reducing the stress and suffering experienced by laboratory animals. However, an outright ban on animal testing ¨C being put to the vote in a popular initiative this coming February ¨C would put an end to progress in medical research.

It¡¯s a good thing if animal testing is widely discussed in society, says Detlef G¨¹nther, but it¡¯s important that these discussions are fair and fact-based.

Whether for squats or sit-ups, the software created by the start-up VAY alerts exercisers about incorrect movements via a smartphone screen. Now the ETH spin-off has been acquired by connected fitness equipment manufacturer Nautilus.

ETH pharmaceutical sciences graduate Nicole Stoffel has shown that iron deficiency reduces vaccine efficacy. Her research is now helping to improve the health of children in developing countries ¨C yet becoming a researcher was not originally part of her plans.

Jos¨¦ Antonio P¨¦rez Escobar studied who was best able to cope with the pandemic. People who are able to deal with negative emotions were particularly successful. This skill can be learned, he says. ?

Scientists at ETH Zurich have developed a new method to determine how proteins are organised on the surface of cells. Insights gained with the technology could lead to the development of novel drugs to fight cancer.

Stanisa Raspopovic connects the digital world of sensors and electrical circuits with the nervous system and its cellular circuits. Now he is the recipient of the 2021 ETH Zurich Latsis Prize.

Chronic stress can decrease the quality of our lives, and have long-term negative effects on our health that may be irreversible. The new Hochschulmedizin Z¨¹rich flagship project STRESS aims to explore the causes of stress and highlight possible treatments.

Biomechanical engineer Bettina M¨¹ller has developed a device that can improve examinations of how scars heal. She hopes her device will help doctors to diagnose skin diseases. ¡°Nimble¡± is set to go to market within two years.

Green tea is seen as healthy and promotes a longer life supposedly due to its high level of antioxidants. Researchers at ETH Zurich have now cast doubt on previous assumptions about how these ingredients work.

Load-bearing, lightweight and now also recyclable: researchers led by Professor Paolo Ermanni were presented with the Spark Award in recognition of an innovative process for production of sustainable composite materials. ETH Zurich awarded the prize to their promising invention, with this year marking the tenth time the award has been given.

Tom Edwardson modified a tiny artificial protein structure so it could be used as a vehicle for RNA molecules and other active substances. He now aims to create a spin-off to bring his development to market.

Technologies that interfere with our brains have great potential. But their ethical implications are such that they may require an expansion of human rights frameworks, argues Marcello Ienca.

In recent years, there have been several incidents of hacked databases, and the hackers published the stolen data on the internet. Are scientists allowed to use such data for their research? ETH Zurich bioethicists Marcello Ienca and Professor Effy Vayena have addressed this question in a paper published in the journal Nature Machine Intelligence. ETH News spoke with Ienca.

From genetics and personalised medicine to health insurance and climate change: at ETH Week 2021, 120 students from all degree programmes and from 31 countries grappled with the topic of ¡°Health for Tomorrow¡±.

Skintegrity.CH is a transdisciplinary consortium for the largest organ of humans, the skin.

ETH Zurich Professor Katrien De Bock and her team have discovered a certain type of blood vessel cell in muscles that multiplies rapidly upon exercise, thereby forming new blood vessels. Researchers can use this to find novel therapies for vascular disorders of the muscle.

Researchers at ETH Zurich have developed a molecule that fluoresces where new tissue is forming in the body. Alongside helping to detect tumours, the molecule could play a significant role in research of wound healing disorders.

Researchers at ETH Zurich have developed a cell culture test to detect substances that are directly or indirectly harmful to embryos. Based on an existing test used for developing new drugs and chemicals, the augmented version is designed to help reduce the number of animal experiments.

Rea Lehner has been running the ¡°Future Health Technologies¡± research programme at the Singapore-ETH Centre since 2020. Together with her team, the ETH researcher is working on the principles of how healthcare can be changed through digital technologies.

Artificial intelligence (AI) is able to recognise the biological activity of natural products in a targeted manner, as researchers at ETH Zurich have demonstrated. Moreover, AI helps to find molecules that have the same effect as a natural substance but are easier to manufacture. This opens up huge possibilities for drug discovery, which also have potential to rewrite the rulebook for pharmaceutical research.

Niko Beerenwinkel, a Professor at the Department of Biosystems Science and Engineering at ETH Zurich in Basel, is working with colleagues from other research institutions to examine wastewater for traces of the coronavirus. He has detected the Delta variant in five out of six Swiss wastewater treatment plants examined, including ones in Zurich and Bern. Recently he spoke with ETH News.

Elena Roos had a tough start in the world of professional sport, but her perseverance took her to the top of the international orienteering rankings. Even a global pandemic can¡¯t stop this ETH alumna.

Researchers at ETH Zurich have recreated a key step in the evolutionary history of viruses in a laboratory experiment. They succeeded in remodeling a natural protein to create capsids capable of storing genetic material.

In the video series "Ask the Expert", experts from ETH Zurich answer questions from the community. In this episode Klaus Eyer talks about vaccinations.

Researchers at ETH Zurich are developing a new filter membrane that is highly efficient at filtering and inactivating a wide variety of air-borne and water-borne viruses. Made from ecologically sound materials, the membrane has an appropriately good environmental footprint.

Researchers at ETH Zurich and the University of Basel have developed a vaccine that protects animals from Salmonella. These bacteria often escape the effects of vaccination by genetically modifying their protective coat. The researchers have succeeded in manipulating this process to lure the bacteria into an evolutionary trap.

Researchers from ETH Zurich and the University of Zurich deciphered the cellular mechanisms through which tendons can adapt to mechanical stresses. People who carry a certain variant of a gene that is key to this mechanism show improved jumping performance.

ETH Fellow Rodrigo Arzate-Mejia is studying how traumatic life experiences affect the brain, with a focus on epigenetic changes in brain cells. ?

Conferring benefits on vaccinated persons by means of a vaccine passport is a controversial issue. Alexander Stremitzer argues that governments are not only legally permitted to lift restrictions for those vaccinated, but may even be obligated to do so. ?

Novel nanoparticles developed by researchers at ETH Zurich and Empa detect multi-resistant bacteria hiding in body cells and kill them. The scientists' goal is to develop an antibacterial agent that is effective where conventional antibiotics remain ineffective.

Machine learning methods help to optimise the development of antibody drugs. This leads to active substances with improved properties, also with regard to tolerability in the body.

Cognitive motor training helps in the fight against Alzheimer¡¯s and dementia, as demonstrated for the first time in a study by an international team of researchers with ETH Zurich involvement. The training platform used was developed by an ETH Zurich spin-off.

We look for certainty in uncertain times. But that is not something statistics can necessarily provide. Tanja Stadler explains why it is important to consider statistical uncertainty through describing the COVID-19 R value estimation which she performs for Switzerland.

Without animal experiments there would be no COVID-19 vaccine: animal testing is essential for medical research. A ban on testing ¨C even a gradual phase-out ¨C would be extremely damaging for research policy, writes Detlef G¨¹nther.

ETH researchers are among the first scientists to have succeeded in propelling microvehicles against a fluid flow using ultrasound. In future, these tiny vehicles are set to be introduced into the human bloodstream, thereby revolutionising the field of medicine.

An ETH Zurich research team is using 3D printing to produce a new type of bioresorbable airway stent. This could greatly simplify the future treatment of upper airway obstruction.