ETH News

Researchers at ETH Zurich have combined two gene editing methods. This enables them to quickly investigate the significance of many genetic mutations involved in the development and treatment of cancer.

A team of three European researchers will develop an imaging method to non-invasively measure the stiffness of moving organs such as the heart. The researchers will be supported by the European Research Council.

Pioneer Fellow Hao Liu uses lasers to produce microfilament structures to grow biological tissue in the lab for research and medicine ¨C from muscle tissue to cartilage. Now he¡¯s working to ready this technology for the market.

Using a new method, researchers at ETH Zurich can measure alterations in the social network of proteins in cells. This work lays the foundation for the development of new drugs to treat diseases such as cancer and Alzheimer¡¯s.

He studies cancer cells and their cellular environment in order to new therapies. Now, ETH Zurich Professor Andrea Alimonti is being awarded the Clo?tta Prize.

Researchers at ETH Zurich have used a drug screening platform they developed to show that an antidepressant, currently on the market, kills tumour cells in the dreaded glioblastoma ¨C at least in the cell-culture dish.

Researchers at ETH Zurich have developed ultra-flexible brain probes that accurately record brain activity without causing tissue damage. This opens up new avenues for the treatment of a range of neurological and neuropsychiatric disorders.?

Researchers at ETH Zurich and The Chinese University of Hong Kong have succeeded for the first time in using remote control to perform a magnetic endoscopy on a live pig. The researchers controlled the probe from Zurich while the animal was on the operating table in Hong Kong.

Not all pain is the same. Depending on the cause, it requires different therapies. A team led by ETH Zurich has now developed a method that enables physicians to better distinguish between physical and psychosocial pain.

A new class of fat cells makes people healthier. The cells consume energy and produce heat through seemingly pointless biochemical reactions.

The brain chemical orexin is crucial when we choose between sport and the tasty temptations that beckon everywhere we turn. This research finding could also help people who find it difficult to motivate themselves to exercise.

Researchers at ETH Zurich have uncovered how colorectal cancer cells colonise the liver. Their findings could open up new ways to suppress this process in the future.

Researchers from ETH Zurich and Empa have developed a hydrogel implant that can help prevent endometriosis, a condition that affects a great many women. This innovation also acts as a contraceptive.

Despite digitalisation being a mainstay in many areas of life, the healthcare sector is lagging behind. J?rg Goldhahn explains what the medical field can learn from banks and travel companies.

The Gloria Cube is ETH Zurich¡¯s newest building in the Zurich City university district. Teaching, research and translation are all carried out in the service of health and medicine here. At the end of last week, ETH Zurich celebrated the laboratory and research building¡¯s inauguration.

Medical students at ETH Zurich build a gripper hand for elbow exoskeletons in a crash course lasting just one week. This course has now been honoured with the 2024 Kite Award, the ETH prize for particularly innovative teaching.

Researchers at ETH Zurich have developed a safe and inexpensive device for reliable blood measurements. It works using a suction cup and could also be employed to diagnose the tropical disease malaria ¨C even by non-medical personnel.

In collaboration with University Hospital Basel, researchers from ETH are investigating the early stages of bladder cancer. Their findings show that future research should also focus on mechanical changes in tumour tissue.

A new computer process developed by chemists at ETH Zurich makes it possible to generate active pharmaceutical ingredients quickly and easily based on a protein¡¯s three-dimensional surface. The new process could revolutionise drug research.

Monitoring and treating a case of multiple sclerosis requires reliable and long-term data on how the disease is progressing in the person in question. Fitness trackers and smartphones can supply this data, as a research team led by ETH Zurich has now shown.

ETH spin-off Scanvio is developing an algorithm that can be used to analyse ultrasound images of the womb on an automated basis. This should enable doctors to diagnose endometriosis more quickly in the future.

Researchers from ETH Zurich and KUNO Klinik St. Hedwig in Regensburg have developed an algorithm that provides an automatic and reliable method of detecting a certain heart defect in newborns.

From new tests and therapies to the fundamental principles of biology: five compelling examples of the benefits of new bioengineering technologies.

Researchers have found genes in the reproductive organs of bulls that influence fertility. The findings can be transferred to humans, as these genes are also present in men.

Roughly one in two wearers of ventricular assist devices are diagnosed with an infection. The reason for this is the thick cable for the power supply. ETH Zurich researchers have now developed a solution to mitigate this problem.

What began as a venture quickly proved its worth: The ETH Bachelor in Human Medicine is well received by graduates and has helped to establish ETH Zurich in the Swiss medical education landscape. In a video, five graduates talk about what makes studying medicine at ETH so special.

Guillain-Barr¨¦ Syndrome is a rare condition in which a person¡¯s immune system attacks the peripheral nerves. People affected suffer from muscle weakness and paralysis. A research team led by ETH Zurich has now clarified the mechanism of this autoimmune disease.

ETH Zurich researchers have found a virus that kills dormant bacteria. This rare discovery could help to combat germs that can¡¯t be treated with antibiotics alone.

There are some striking parallels between how skin wounds heal and how malignant tumours grow. Cell culture can help us understand the mechanisms involved ¨C but animal testing still has a role to play.

On the road to recovery, patients come into contact with clinicians from a whole range of disciplines. The importance of targeted collaboration between these disciplines is something medical students learn early on at ETH Zurich.

ETH Zurich researchers have shown for the first time that microvehicles can be steered through blood vessels in the brains of mice using ultrasound. They hope that this will eventually lead to treatments capable of delivering drugs with pinpoint precision.

No¨¦ Brasier is fascinated by the emerging field of sweat analysis. He plans to measure the effect of heat stress directly on people¡¯s skin ¨C and help them protect themselves from health risks.

For her doctoral project at ETH Zurich, Sabrina Badir developed a device that determines the risk of premature birth. Today she is the CEO of spin-off Pregnolia, and her certified measuring device is being used in more than 20 clinics and medical practices.

What¡¯s the best way to translate research findings into clinical practice? A discussion with Monika J?nicke, CEO of the University Hospital Zurich, Rahel Kubik, head of radiology at Kantonsspital Baden, and Christian Wolfrum, VP for Research at ETH Zurich.

After suffering a severe case of Covid-19, Roger Gassert discovered for himself how important a role rehabilitation plays in recovery. The ETH Professor of Rehabilitation Engineering now plans to waste no time ensuring that patients profit from his developments.

Marianne Schmid Daners was already fascinated by the human-technology interface when she worked as a registered nurse. Since graduating with a degree in mechanical engineering and a doctorate in biomedical engineering, she has been developing biomedical devices for the treatment of heart failure and hydrocephalus.

Mohammed Said is in his third semester of the Bachelor of Human Medicine at ETH Zurich. He plans to work abroad as a doctor and researcher one day and put his knowledge into practice in countries where people are not as fortunate as in Switzerland.

Clara Ehrenzeller studied human medicine at ETH Zurich. Aspects of her course that she will never forget were her six-week research internship at a children¡¯s hospital in Canada and her deployment at the Kantonsspital Baden. She is currently pursuing a Master¡¯s degree in Ticino.

Researchers at ETH Zurich have now shown that a previously unknown protein plays a key role in a congenital malformation of the heart. Their findings point the way towards new treatment options.

The ETH Zurich Latsis Prize goes to Professor Inge Herrmann, and the Lopez-Loreta Prize to researcher Alexandre Anthis. The two scientists have been working together for five years to develop new materials and applications for medicine.

ETH Zurich researchers are illuminating what can happen when cells exceed their normal size and become senescent. Their new findings could help to optimise cancer treatments.

How to bring a diagnostic process that has endured for 100 years into the digital age? Two researchers from ETH Zurich and the University of Zurich are developing a robotic platform that enables a more accurate diagnosis of cancer cells by rapidly quantifying tissue samples in their entirety.

Stimulating the brain with gentle sounds during deep sleep significantly enhances cardiac function, according to a new study. This discovery could have implications not only for cardiovascular diseases but also for competitive sports, among other areas.

Experts from ETH Zurich, the University of Zurich, and the University Hospital Zurich have used machine learning to jointly create an innovative method. This new approach can predict how individual cells react to specific treatments, offering hope for more accurate diagnoses and therapeutics.

Researchers at ETH Zurich have developed a suction cup that allows medications to be absorbed through the mucosal lining of the cheeks. This new approach could spare millions of patients the pain and fear associated with injections.

Fondation Botnar is donating an additional CHF 50 million to the University of Basel and ETH Zurich to expand the activities of the joint Botnar Research Centre for Child Health (BRCCH). This support will allow to create six new professorships with a research focus on paediatric digital health.

"We will rock you": ETH Zurich researchers are developing a gene switch that triggers insulin release in designer cells by playing certain rock and pop songs.

The ability to utilize a mere single alternative food source is all it takes for diarrhoea causing Salmonella bacteria to bloom when a gut is already colonized by a closely related strain, according to researchers from ETH Zurich. This coexistence enables the exchange of antibiotic resistance.

ETH Zurich professors Mustafa Khammash and Marc Pollefeys are each recipients of a prestigious Advanced Grant currently awarded by the Swiss National Science Foundation, rather than the European Research Council.

A new method allows large quantities of muscle stem cells to be safely obtained in cell culture. This provides a potential for treating patients with muscle diseases ¨C and for those who would like to eat meat, but don¡¯t want to kill animals.

ETH Zurich molecular biologist Mandy Boontanrart is researching gene therapies that could be used to cure two of the most common types of inherited anaemia. She has now developed a promising approach for so-called beta-hemoglobinopathies.

Science often runs ahead of legislation ¨C and this is now also true for research on embryo-like cell aggregates from human stem cells. Bioethicist Alessandro Blasimme of ETH Zurich explains why this controversial topic calls for legal clarity.

The pathogens that cause urinary tract infections are becoming increasingly resistant to antibiotics. ETH Zurich researchers have now developed a rapid test and a new therapeutic approach using bacteria-infecting viruses known as phages.

A research team from ETH Zurich and the Paul Scherrer Institute PSI together with the Baden Cantonal Hospital and the University Hospital Zurich wants to improve a method for diagnosing breast cancer. ?

The way the brain regulates pupil size is different from previously thought: fundamentally responsible is the neurotransmitter orexin, as researchers at ETH Zurich have now shown. This discovery could well alter our understanding of consciousness and illnesses such as narcolepsy and Alzheimer¡¯s.

ETH Zurich and Roche are joining forces in Basel to advance the development of new methods that facilitate the search for medicines. Together, they will train specialists for the biomedical challenges of our time.

Kantonsspital Baden (KSB) and ETH Zurich have been working together since 2017, mainly in teaching initially, but increasingly in clinical research. Now three ETH professors are moving into new premises on the hospital¡¯s healthcare campus. Together, they want to make findings from basic research available for the benefit of patients.

The ETH spin-off aiEndoscopic has developed a device that should make intubation easier and safer in the future. It combines artificial intelligence and robotics.

Researchers at ETH Zurich and Empa have developed a patch with a sensor function. It can be used to seal wounds in the abdomen after surgery. The polymer patch warns before the occurrence of dangerous leaks on sutures in the gastrointestinal tract.

Bachelor¡¯s students at ETH Zurich were given a year to turn their original ideas into finished products. ETH News presents videos of two of these projects.

The cells of our body interact with their immediate environment. Researchers have now studied this interaction in detail. In time, they hope to use these findings for improved diagnosis and treatment of wound-healing disorders and cancer.

Despite approved treatments being available, multiple myeloma remains incurable. But researchers at ETH Zurich and University Hospital Zurich set out to improve treatment outcomes by testing hundreds of existing therapeutics outside the body to predict their effectiveness.

Researchers at ETH Zurich have analysed the bird flu epidemic caused by the H7N9 strain that affected China from 2013 to 2017. New phylogenetic trees will help to improve monitoring of future bird flu epidemics.

Computer simulations have helped researchers understand in detail how pharmaceutically active substances cross cell membranes. These findings can now be used to discover new drug candidates more efficiently.

A team led by ETH Zurich chemical engineers Chih-Jen Shih and Andrew deMello have developed a rapid test system made of smart graphene paper. It only costs a few cents per test strip, is easy to use but is as accurate as lab measurements. The approach will impact more than just disease monitoring.

Increasingly dense cell clusters in growing tumours convert blood vessels into fibre-filled channels. This makes immune cells less effective, as findings by researchers from ETH Zurich and the University of Strasbourg suggest.

Cancer patients might one day benefit from being administered immune cells from healthy donors. But as things stand, receiving donor cells can cause severe or even fatal immune reactions. A researcher at ETH Zurich has now developed a technology that avoids these.

The LOOP Zurich research centre is creating a central platform for the exchange of health data between the University of Zurich, ETH Zurich and the four university hospitals. This will allow data to be utilised quickly and easily to the benefit of patients.?

New research offers potential benefits for those affected by the hereditary metabolic disease methylmalonic aciduria. By combining the results of multiple molecular analyses, scientists can better diagnose this rare and severe disease. In the future, an improved understanding of the disease might also improve treatment options.

A special year is soon coming to an end. In 2022, much has been researched, developed and invented at ETH Zurich. ETH News looks back on an eventful past year.

A new study by various Swiss universities shows that aerosols in indoor air can vary in acidity. This acidity determines how long viruses remain infectious in the air ¨C with profound implications for virus transmission and strategies to contain it.

The LOOP Zurich research center combines expertise from ETH Zurich, the University of Zurich and the four university hospitals in Zurich with the aim of developing more personalized therapies. Two new projects supported by The LOOP Zurich target urinary tract infections and obesity respectively.

A needle and some blood are usually needed for medical diagnostics.

ETH Zurich researchers have found that a set of proteins have different shapes in the spinal fluid of healthy individuals and Parkinson¡¯s patients. These could be used in the future as a new type of biomarker for this disease.?

Researchers from ETH Zurich and the University of Zurich are taking magnetic resonance imaging a step further. With their new method, they can visualise metabolic processes in the body. Their objective is to improve the future diagnosis and treatment of heart disease.

Researchers at ETH Zurich are planning to use magnetic bacteria to fight cancerous tumours. They have now found a way for these microorganisms to effectively cross blood vessel walls and subsequently colonise a tumour.

Scientists have a duty to initiate a dialogue with the public on cellular engineering, says Daniel M¨¹ller. The discussion must be held now ¨C before complex engineered cellular systems are ready for widespread use in humans.

Autonomous virtual humans that move and behave naturally are Siyu Tang¡¯s vision. One area from which the computer scientist draws inspiration are our behavioural patterns. Collaboration with architects and surgeons provides further input ¨C and it also reveals the enormous potential of virtual people.

ETH Zurich biologist Daniel Richter has developed a method that enables proteins to be linked to a drug molecule or biomarker with a high level of stability. He plans to use this method in the future to identify tumour cells and open the door to more effective cancer drugs.

ETH Pioneer Fellow Alexandre Anthis has developed a patch that seals surgical sutures on the intestines or the stomach. The material designed can also detect any leakage at an early stage ¨C thus preventing serious complications.

Most vaccines require constant refrigeration during shipment to remain effective. An international research team led by ETH Zurich has now developed a special hydrogel that vastly improves the shelf life of vaccines, even without refrigeration. The development could save many lives and lower the cost of cold chains.

Researchers of the Wellcome Sanger Institute and ETH Zurich have created the first full connectivity map of the human immune system, showing how immune cells communicate with each other and ways to modulate these pathways in disease.

ETH spin-off Nanoflex has developed a magnetically steerable catheter for quick and safe stroke treatment that no longer requires surgeons to be on site.

ETH researchers found that in mice, long-lived embryonic macrophages in the lungs die upon aging and during infection and are replaced by inflammatory bone marrow-derived macrophages. This causes severe disease progression when infected with viral flu.

The latest CRISPR-based genome editing systems function more like molecular taxis rather than a pair of molecular scissors. This makes them much safer for patients who will soon benefit from gene therapies, as Eric Aird explains.

Researchers at ETH have shown that cases of opioid poisoning and the prescription of opioids have increased sharply in Switzerland over the past 20 years. Although the situation is not as serious as in North America, the risk should not be underestimated.

A new study shows that breast cancer metastases form more efficiently while patients are sleeping. This finding, in a study led by researchers at ETH Zur-ich, could significantly change the way cancer is diagnosed and treated in future.

The multidisciplinary Zurich research team Liver4Life has succeeded in doing something during a treatment attempt that had never been achieved in the history of medicine until now: it treated an originally damaged human liver in a machine for three days outside of a body and then implanted the recovered organ into a cancer patient. One year later, the patient is doing well.

The VIEshunt student team aims to benefit patients by developing an intelligent shunt able to regulate the intracranial pressure.

Researchers from ETH Zurich, University Hospital of Bern and the University of Bern have equipped gut bacteria with data logger functionality as a way of monitoring which genes are active in the bacteria. These microorganisms could one day offer a noninvasive means of diagnosing disease or assessing the impact of a diet on health.

From diagnostics to treatment, the biochemical method developed by Daniel Richter, Edgars Lakis and J?rn Piel paves the way for a diverse range of applications in research and medicine. The researchers received the ETH Zurich Spark Award 2022 for their innovative solution.

A presumed consent system for organ donation, which is to be put to the vote in Switzerland, would likely increase the organ donation rate, writes bioethicist Agata Ferretti. In her view, however, there is an even better solution: the obligation to decide.

Climate change, pandemics and cyber attacks are risks that have long been in the public spotlight. But there are also risks that ETH researchers consider are still being given too little attention. Photographer Tina Sturzenegger has captured the scenarios on film.

Data contains much more than just the information on the surface. With statistics, deeper cause-and-effect relationships can be brought to light. This is what Alexander Marx is researching as a Fellow at the ETH AI Center using artificial intelligence. One of his goals is to be able to make predictions regarding diabetes in children. ?

Bacteria show great promise as a source of active ingredients. Using computer-based genome analysis, researchers at ETH Zurich have now discovered a new class of natural products that might one day serve as antibiotics.

ETH researchers have used computer simulations to show that tissue structure in different types of cancer is decisive in determining how a tumour develops. This information could make it possible to treat patients in a more targeted manner in future.

Step-by-step researchers at ETH Zurich are working towards reducing the global impact of cancer. In recognition of World Cancer Day - a day dedicated to the promotion of research for curing and preventing the disease, we share a collection of recent research insights. #WorldCancerDay #CloseTheCareGap

Johannes Bohacek explains why it¡¯s misleading to think we can completely replace animal testing with alternative methods, and why we should lower rather than raise the hurdles to research.

Viruses that infect bacteria could one day replace antibiotics because they precisely attack only specific pathogens. Researchers at ETH Zurich are now showing that this is not always the case. This new finding is important because bacterial viruses can transfer antibiotic resistance genes.

It¡¯s a good thing if animal testing is widely discussed in society, says Detlef G¨¹nther, but it¡¯s important that these discussions are fair and fact-based.